In this episode, Rhonda explains what NAD+ is and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts.
NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective – and safe – long-term in humans is still a big question.
▶︎ Get the episode's show notes, timeline, and more
https://www.foundmyfitness.com/episodes/nad-nr-nmn
Chapters
00:00:00 - Introduction
00:01:01 - Aging
00:02:47 - Overview
00:07:35 - Depletion
00:09:19 - Supplementation
00:11:26 - Animal studies
00:13:47 - Cancer
00:15:57 - Dosage
00:25:44 - Human data
00:28:25 - Storage
00:29:00 - Recap
▶︎ Detailed overview of NAD+
https://www.foundmyfitness.com/topics/nad
▶︎ Detailed overview of nicotinamide riboside
https://www.foundmyfitness.com/topics/nicotinamide-riboside
▶︎ Detailed overview of nicotinamide mononucleotide
https://www.foundmyfitness.com/topics/nicotinamide-mononucleotide
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▶︎ Gain valuable insights by running your raw genetic data through the FoundMyFitness report
https://www.foundmyfitness.com/genetics/sirtuin
@FoundMyFitness4 years ago - Intro. - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. - Overview of NAD+ - NAD+ plays an important role in mitigating DNA damage. - Excessive DNA damage can decrease NAD+ levels by 20-30%. - Lymphoblastoid cells from centenarians show increased PARP-1 activity. - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. - Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. - Plausibility of dosing: comparing animal and human doses. - Tissue-specific metabolism and bioavailability of NR and NMN. - Oral administration of NAD produces NR and NMN in the intestine. - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. - Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). - Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. - Concluding thoughts and recap. .....Expand286
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@bahb004 years agoCongratulations rhonda you have smashed the record for total mentions ofand nicotinamidewithout stuttering, giggling or entering a comatose state. Kudos! 247
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@Spicydoc12 years agoHow lucky we are to have dr. Patrick in our lives. She is amazing. Knowledge just oozes out of her. 16
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@pablopolski12284 years agoConcise, comprehensive, and articulate. I don' t even need to speed it up to get through the information. Well done. 395
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@scott.joshua4 years agoWhat a herculean effort and a testament to your ability to grind it out for hours on end. Youre incredible rhonda. 28
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@keng77582 years agoI simply love your style of presenting with the latest facts. You speak fast, which i like! The data you provide and the research you do prior to presenting. ...Expand5
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@chrisbenton53354 years agoExcellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique. 123
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@nolimit11524 years agoA very professional very well presented lecture. English is my 4th. Language and i did not have any real problem to understand it and learn from it. Doc, i really appreciate your effort to create this video. Thank you. 9
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@DDFaye743 years agoThis is just about the most thorough and intelligent pp presentation i' ve ever seen. She is one smart lady! Wow.
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@roblovegreen4 years agoBecause of you, i started loving myself with broccoli sprouts. I grow them too. Sulforaphane for the win! Thank you. 61
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@turinhorse4 years agoFew notifications on youtube get me as excited as a video from dr. Rhonda patrick. 3
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@richrozmarn38174 years agoGreat presentation, thank you so much. I take nad with r-lipoic acid, d-ribose and resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60. 56
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@optimizewithscience88834 years agoIt is a fascinating topic and i love how scientific dr. Patrick approaches it! 40
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@davidevans14204 years agoRarely do we find in the study oflike presented in this video, yet at the same time rhonda is able to get to her final conclusion without everyone in the weeds. Extremely well done. Combined with dr. Nicholas pericone and dr. Jason fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health. ...Expand24
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@mvrao29last yearIt appears that dr rhonda does a lot of preparation and compilation of subject matter for making each video. Her tone and presentation skills are excellent.. ...Expand1
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@Noveleffect4 years agoI really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough. 5
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@juneallison70523 years agoDr. Rhonda this is the best explanation i' ve heard on this topic. So thorough and well thought out. Thank you. 2
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@tonywestbrook98764 years agoI learn so much here by your presentation and documentation. Thank you rhonda for taking, what must be a lot of time to put all of this documentation together! 29
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@Healitnow4 years agoGreat video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now i will be going. ...Expand5
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@gururajbsavakar71544 years agoCongratulations! firstly for the, pleasant, patient presentation, with amazing revelations of test results of nad, decline with age, using boosters extremely a great masterly study/ & presentation of all pros- cons of all eventualities. with a final recap! thanks for this useful educative share! Many regards!. ...Expand5
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@18KarlaG4 years ago5 months later and i' m still coming back to relisten to this video. Very informative and so well put together. 2
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@wolframluchner53164 years agoExemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content! 7
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@rickm68073 years agoHoly crap, this was amazing. This 30 minute video took me 2 hours to get through. Had to pause and read and then pause and research. Thank you! 1
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@ALulzyApprentice2 years agoThis is the most comprehensive video i have seen on this topic. You are a gem. Thank you.
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@heroicalx7864 years agoDr. Rhonda, the people' s champion! 46
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@TheEatraum4 years agoDamn. I need an iv of this channel straight into my brain. Oh, and that other stuff you were talking about, as well. 121
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@tomjones23484 years agoI like to watch informational videos like this while doing my hour of piano warm ups. Do it on this one. Need to give this video my 100% attention. Thanks dr. Patrick. 1
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@cuentadeyoutube59034 years agoBest unbiased recap of nad+, nr and nmn. Thank you! Suscribed! 3
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@ngallure4 years agoSo great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless. ...Expand1
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@Libertas_P774 years agoGreat video rhonda, thank you for all you' re doing and the quality information with such strong scientific detail. 3
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@profitfever4 years agoSo glad you covered this. Been listening to lifespan on audio book and he' s one of the leading scientists on this research. 8
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@mookywilson10544 years agoDoc! Your the best! I wish there were more docs like you. 4
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@JosetteBadger2 years agoYou remind me of my favorite med school professor- one of my favorite instructors of all time thanks for the clear and concise video!
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@tomprovan68174 years agoThis is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as i am concerned thank you for this video.
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@johnhunt37594 years agoThank you. Please do not stop helping people the way you do. 1
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@tominatr3 years agoI could look and listen to her all day.
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@echomanechoman784 years agoThe beston youtube that explains nad+.
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@squamish42444 years agoNad+ is a miracle drug and no mistake. The hype is real. It has had a profound effect on my mental and physical health at the age of 41, after many years. ...Expand3
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@lightinthedark332 years agoWhat a great video doc. i saw you in person once but did not want to bother (fashion valley) i would consider you to be one of my heros in t id="hidden17"he health field ive been greatly inspired by you and dr. Sinclair to understand health from a scientific basis in hopes that i can pass this knowledge onto my mother who has ms and the rest of my loved ones. thank you for what you do. ...Expand
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@pravoslavn4 years agoJust found youryour presentations areas the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. Please keep up the good work! 2
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@dukecityrecordslast yearThank you dr. Patrick i appreciate the honest review as someone who was just looking into this i really appreciate the data and information you' ve brought forward. Please continue to be an amazing doctor! 1
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@richardwheeler13874 years agoBest presentation on the nad/nmn potential and current status i have seen anywhere.
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@unclejoe33974 years agoExciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime i' ll continue my exercise, sauna, and clean diet. Thanks! 1
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@spockboy4 years agoThank you so much for bringing us this information doctor. Using your great intelligence for altruistic purposes is both rare and wonderful. 3
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@andrewmooreone4 years agoSuperb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you! 1
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@stephenhurst13484 years agoThank you so much for the thorough long-form video, all of this information is very important. 1
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@LaunchMedicalMedia4 years agoThis is a wonderful video. We will probably be sending our patients this video when they ask about nad+ from now on!
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@mr.reberdo61414 years agoBest video ive seen on the subject. thank you! 4
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@DavidSchwartzjr4 years agoBeen looking into this a bit recently. Thanks for the new upload, rhonda! 1
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@equsnarnd4 years agoI' d like to see you do a video on the role of niacin (nicotinic acid) on supplying the molecules for the manufacture of nad+. 11
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@CompSource4 years agoWow amazing job and the best, most concise source of information i' ve ever seen for nad oh, great job! 1
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@MrJamesdryable4 years agoI weigh exactly 180 pounds. This is great. 42
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@kuo-yingwang22732 years agoExcellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches.
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@peterdavila30452 years agoI' m 66 years old. I started taking 1g a day of apigenin a few months ago. Apigenin is one of the ways to raise nad+. It is amazing how much energy my diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (walnuts, cashews) seeds (flax, hemp, chia) dark chocolate (80% cocoa) i do drink lots of coffee. I don' t drink cow milk but almond milk instead. I don' t drink alcohol. live long enough to live foreever. ...Expand22
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@firehorse_44alpha-omega994 years agoExcellent lecture. thank you for this presentation dr. cheers. 10
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@realtriumph4 years agoThank you for the video. I have been taking tru nigen (nr) for about two months at 350 mgs. What i have noticed is a slight increase in energy, and focus.. ...Expand14
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@2kosio4 years agoCongratulations - it' s pretty rare to be able to see such good quality presentation for so complex topic and compressed in so condensed time. 1
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@lucmarcoux21444 years agoWow, thank you for that full explanation. I have cut sugars, am into intermittent fasting, with 4 prolong 5day fast a year, and now looking into mr sinclair' s . ...Expand1
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@noemiromero47294 years agoYou are amazing! This material is so useful! 12
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@Hgulix624 years agoI think you can' t make more concise and comprehensible than this. 1
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@BD-xf7yn3 years agoExcellent! Conclusion: fasting, less calories, regular exercise increases nad level we all need to wait for using supplement at this point till more data available! 2
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@jhumm0074 years agoI' ve been taking 1g of nr daily for 2 years. I find that i don' t get jet lag or hangovers anymore. My contribution to this fascinating science. 16
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@lpngolfer4 years agoThank you so much for giving this teaching on this topic. Valuable information! 2
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@michelleguerrero28484 years agoDr. Talks to us like we could really get it. I do! 15
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@Morroccomethodraw4 years agoSo helpful + informative for learning about aging. Thank you for this video! 2
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@dr.stevehrubyd.c.36664 years agoThank you dr patrick this is above and beyond anything that is out there. 1
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@billyjoehuggins4 years agoThank you, dr. Rhonda patrick! Great information! 2
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@peterwu50914 years agoI' m exactly 180lb, thank you for this vid! 3
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@Roger-Bowman2 years agoStellar presentation as always, thank you dr. Patrick!
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@jawi4994 years agoGood work! You certainly did the research and can explain it with great accuracy. Thank you.
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@ramonmensink94584 years agoGreat video rhonda! i was wondering if it makes sense to take a nr/nmn supplement while also ingesting as you also explain in the video, the nad/nadh ratio in the cell increases when then such a nad boosting supplement would need to be taken in a fasted state wouldn' t it? or is the pathway of either nr/nmn supplement somehow separated from the metabolic pathway when a cell is in a fasted state?. ...Expand4
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@davidg.johnson72082 years agoLoved your interview with dr. Daivid sinclair! The meeting of two great doctors! Hope you have another with him! Maybe get a pre-copy of his new book to come out soon for an interview?
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@watchutalknboutwillis18743 years agoIts bonkers to conceive that this is free. Ty dr patrick.
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@isabellaholden86934 years agoAmazing video. Thank you for the brilliantly explained content. 5
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@danielthiel79132 years ago@dr. Patrick - i' m curious if taking nad+ injections is an effective substitute for nad boosters?
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@lsporter882 years agoThat was a very thorough explanation dr. Patrick. Thank you.
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@robo2654 years agoWow talk about informative video thank you, ive been taking a product which contains nicotinamide 250 mg twice a day with botanical mix alpha lipoic a the company claim that despite all the hype surrounding the use of precursors such as nr and nmn to boost nad+, our cells actually make nearly all of the nad+ they need using nam, as you described in your presentation. they go on to say that as we get older, levels of the nampt enzyme are known to decline and the salvage pathway becomes inefficient at converting nam into nad+. In fact this is known to be one of the main reasons that cellular nad+ declines as we get older. This means that if we want to make sure that nam doesnt build up in the cell, then we must make sure that nampt and the salvage pathway are working optimally, like they were in young cells. Rather than simply trying to fix falling nad+ levels by putting more raw material into the cell (using precursors) the product is designed to fix the underlying reasons why nad+ is actually declining, namely the failing salvage pathway. i am however concerned of the effect of nicotinamide on sirt2, they claim however that nicotinamide does not effect sirtuins if it doesnt hang around for a long time when the salvage pathway is working properly. I just wondered what your thoughts are on this. Again many thanks for your very detailed video. ...Expand2
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@tahoon20094 years agoAwesome, best nad video so far, you saved days of research in such information dense video, awesome work.
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@catman44714 years agoI' ve been taking a low doseage of nmn for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg i' ve had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. my mind is foggy most of the time and the nmn has not done anything for that, but i certainly feel the difference in energy levels, it' s really amazing. i also found that after a few days i had to stop the nmn for a couple of days as it seemed to be making me feel more groggy, so i now take it 2 days on, 2 days off. the brand i' m using is an american brand called revgenetics, and it' s called advanced nmn, in capsule form. I know it' s also available in powder form too. It' s quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but i can assure anyone that the effects at the doseage i am on are truly amazing. ...Expand7
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@jaydon12324 years agoThank you for such an educational clip. Please keep it up. 3
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@clsatc4 years agoDr. Rhonda - you are such an amazing speaker and i have learned so much from you. I just want to respectfully remind you that the word does not have the " sh" sound in it. So many people make that same mistake so probably most don' t notice it. ...Expand
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@alfredvincent138254 years agoGreat concise presentation as always. Thank you. 2
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@claystone77293 years agoThank you rhonda i will watch this again you explain nad+, nr and nmn excellent easy to follow. I will come back to this video on referencing one of the best out there. God bless you.
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@lookmomitsthatboy18694 years agoI found out about dr ronda a few months ago! Im 26 and havent became 27 yet! I owe it all to her and my broccoli sprouts.
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@bneymanov4 years agoInstantly one of my favorites videos on youtube. Thank you so much, rhonda! 2
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@moonoom7644 years agoPlease rhonda, the floxing community needs you to make a video abouttoxicity! 16
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@CharlesReedPi4 months agoFascinating, thanks for explaining the more direct clinical results.
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@astonfallen52724 years agoThanx rhonda, for an excellent presentation! I' ve heard about this mainly from david sinclair - i am following closely, and i look forward to more input from you!
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@cs-cg9wl4 years agoWow, your speech is so much better. Speed, clarity, cadence, all resulting in you being much more pleasant to listen to while keeping all that detail intact.. ...Expand
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@simozamb78354 years agoThank you so much! I am looking forward to viewing other videos from you! 1
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@danno18003 years agoVery helpful comprehensive much appreciated! 2
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@DrMichaelMoeller4 years agoI personally get NAD IVs@ and use them with my patients and notice an increase in energy and improved cognition. 31
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@sunshinehappyfuntimes4 years agoThank you for being honest and thorough. You are the best.
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@vibhaspalding64572 years agoI have nmn and nad both in capsule form. Vitamin d, k2, quercetin, berberine, creatinine, alpha lipoic acid and some other supplements. After hip operation. ...Expand
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@MrVeteranhawk3 years agoI did 10 push ups for every time she said nr or nmn, i don' t have to workout until the year 2023 now. Lol. But great presentation, very helpful for. ...Expand2
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@rzomg4 years agoAmazing skills to flood my brain with huge amounts of information. I know how its gonna feel when ai' s are smarter than us all its the same feeling i get when i listen to dr. Rhonda. 2
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@stephenhurst13484 years agoI wish these were put on the podcast app so i could listen while i drive or work.
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@devinlauwerier4044 years agoI just hope she appreciates me keeping this comment classy. -thank you, rogan again soon? 17
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@metallicamadsam3 years agoThis is an excellent summary of the literature. Thankyou.
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@transformationcentral75012 years agoHi rhonda, have you considered an update on your analysis of nad boosters? enjoyed your take on them and certainly interested in your opinion! 2
Related videos for NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide:
- Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells.
- Overview of NAD+
- NAD+ plays an important role in mitigating DNA damage.
- Excessive DNA damage can decrease NAD+ levels by 20-30%.
- Lymphoblastoid cells from centenarians show increased PARP-1 activity.
- Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan.
- Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan.
- NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes.
- Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio.
- NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age.
- Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal.
- NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents.
- In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide.
- Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy.
- Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity.
- Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory.
- A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice.
- NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice.
- Plausibility of dosing: comparing animal and human doses.
- Tissue-specific metabolism and bioavailability of NR and NMN.
- Oral administration of NAD produces NR and NMN in the intestine.
- Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain.
- Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health).
- Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%.
- Concluding thoughts and recap. .. ...Expand 286
firstly for the, pleasant, patient presentation, with amazing revelations of test results of nad, decline with age, using boosters extremely a great masterly study/ & presentation of all pros- cons of all eventualities.
with a final recap!
thanks for this useful educative share! Many regards!. ...Expand 5
thanks for the clear and concise video!
i saw you in person once but did not want to bother (fashion valley) i would consider you to be one of my heros in t id="hidden17"he health field ive been greatly inspired by you and dr. Sinclair to understand health from a scientific basis in hopes that i can pass this knowledge onto my mother who has ms and the rest of my loved ones.
thank you for what you do. ...Expand
thank you! 4
live long enough to live foreever. ...Expand 22
thank you for this presentation dr.
cheers. 10
we all need to wait for using supplement at this point till more data available! 2
i was wondering if it makes sense to take a nr/nmn supplement while also ingesting
as you also explain in the video, the nad/nadh ratio in the cell increases when
then such a nad boosting supplement would need to be taken in a fasted state wouldn' t it?
or is the pathway of either nr/nmn supplement somehow separated from the metabolic pathway when a cell is in a fasted state?. ...Expand 4
they go on to say that as we get older, levels of the nampt enzyme are known to decline and the salvage pathway becomes inefficient at converting nam into nad+. In fact this is known to be one of the main reasons that cellular nad+ declines as we get older. This means that if we want to make sure that nam doesnt build up in the cell, then we must make sure that nampt and the salvage pathway are working optimally, like they were in young cells. Rather than simply trying to fix falling nad+ levels by putting more raw material into the cell (using precursors) the product is designed to fix the underlying reasons why nad+ is actually declining, namely the failing salvage pathway.
i am however concerned of the effect of nicotinamide on sirt2, they claim however that nicotinamide does not effect sirtuins if it doesnt hang around for a long time when the salvage pathway is working properly. I just wondered what your thoughts are on this. Again many thanks for your very detailed video. ...Expand 2
my mind is foggy most of the time and the nmn has not done anything for that, but i certainly feel the difference in energy levels, it' s really amazing.
i also found that after a few days i had to stop the nmn for a couple of days as it seemed to be making me feel more groggy, so i now take it 2 days on, 2 days off.
the brand i' m using is an american brand called revgenetics, and it' s called advanced nmn, in capsule form. I know it' s also available in powder form too. It' s quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but i can assure anyone that the effects at the doseage i am on are truly amazing. ...Expand 7
-thank you, rogan again soon? 17
have you considered an update on your analysis of nad boosters?
enjoyed your take on them and certainly interested in your opinion! 2